| 别名 | Amplaxin; cortactin; CTTN; EMS1; Oncogene EMS1; Src substrate cortactin; SRC8; |
| 基因名称 | Cortactin |
| 蛋白名称 | Cortactin |
| 推荐应用 | |
| 反应物种 | Human Mouse Rat |
| 存储缓冲液 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Human Gene Link | 13043; |
| Human Swissprot No. | Q14247 |
| Mouse Gene ID | 13043; |
| Mouse Swissprot No. | Q60598 |
| Rat Gene ID | 60465 |
| Rat Swissprot No. | Q66HL2 |
| 特异性 | Endogenous |
| 稀释度 | IHC 1:100-1:500;WB 1:5000~1:10000 |
| 参考分子量 | MW(Observed): 80 kDa |
| 预测分子量 | MW(Calculated): 62 kDa |
| 运输及保存条件 | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 宿主 | Rabbit |
| 同种型 | IgG,Kappa |
| 背景介绍 | Cortactin a cytoskeletal protein that that is involved in coordinating actin reorganization during cell movement. Localizes at the leading edge of lamellipodia during cell migration. Its amino-terminal acidic domain associates with the Arp2/3 and WASP complex at F-actin branches. |
| 细胞定位 | Cytoplasm , cytoskeleton . Cell projection , lamellipodium . Cell projection , ruffle. Cell projection , dendrite . Cell projection . Cell membrane ; Peripheral membrane protein ; Cytoplasmic side . Cell projection , podosome . Cell junction . Cell junction , focal adhesion . Membrane , clathrin-coated pit . Cell projection , dendritic spine . Cytoplasm , cell cortex . Colocalizes transiently with PTK2/FAK1 at focal adhesions (By similarity) . Associated with membrane ruffles and lamellipodia. In the presence of CTTNBP2NL , colocalizes with stress fibers (By similarity) . In the presence of CTTNBP2 , localizes at the cell cortex (By similarity) . In response to neuronal activation by glutamate , redistributes from dendritic spines to the dendritic shaft (By similarity) . Colocalizes with DNM2 at the basis of filopodia in hippocampus neuron growth zones (By similarity) . . |
| 纯化 | Protein A |
| Clonality | Monoclonal |
| 修饰类型 | Unmodified |
| 细胞定位 | Cytoplasm , cytoskeleton . Cell projection , lamellipodium . Cell projection , ruffle. Cell projection , dendrite . Cell projection . Cell membrane ; Peripheral membrane protein ; Cytoplasmic side . Cell projection , podosome . Cell junction . Cell junction , focal adhesion . Membrane , clathrin-coated pit . Cell projection , dendritic spine . Cytoplasm , cell cortex . Colocalizes transiently with PTK2/FAK1 at focal adhesions (By similarity) . Associated with membrane ruffles and lamellipodia. In the presence of CTTNBP2NL , colocalizes with stress fibers (By similarity) . In the presence of CTTNBP2 , localizes at the cell cortex (By similarity) . In response to neuronal activation by glutamate , redistributes from dendritic spines to the dendritic shaft (By similarity) . Colocalizes with DNM2 at the basis of filopodia in hippocampus neuron growth zones (By similarity) . . |
| 组织表达 | Ubiquitous expression |
周一至周日 8:00-18:00
