| 别名 | DYSF; Dysferlin; Fer-1-like protein 1; |
| 基因名称 | Dysferlin |
| 蛋白名称 | Dysferlin |
| 推荐应用 | |
| 反应物种 | Human Mouse |
| 存储缓冲液 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Human Gene Link | 8291 |
| Human Swissprot No. | O75923 |
| Mouse Gene ID | 26903 |
| Mouse Swissprot No. | Q9ESD7 |
| 特异性 | Endogenous |
| 稀释度 | IHC 1:100-1:500;WB 1:500~1:1000 |
| 参考分子量 | MW(Observed): 280 kDa |
| 预测分子量 | MW(Calculated): 237 kDa |
| 运输及保存条件 | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 宿主 | Rabbit |
| 同种型 | IgG,Kappa |
| 背景介绍 | Dysferlin Key calcium ion sensor involved in the Ca(2+)-triggered synaptic vesicle-plasma membrane fusion. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress. Belongs to the ferlin family. Interacts with CACNA1S. Interacts with ANXA1; the interaction is Ca(2+)- and injury state-dependent. |
| 细胞定位 | Cytoplasmic vesicle, Endosome, Extracellular exosome, Plasma membrane, T-tubule. |
| 纯化 | Protein A |
| Clonality | Monoclonal |
| 修饰类型 | Unmodified |
| 细胞定位 | Cytoplasmic vesicle, Endosome, Extracellular exosome, Plasma membrane, T-tubule. |
| 组织表达 | Skeletal muscle, Cardiac muscle, Rhabdomyosarcoma, Cardiac sarcoma, Muscular dystrophy tissue |
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