| 别名 | TPH1;MGC119994;TPRH;TRPH;Tryptophan 5-hydroxylase 1; Tryptophan Hydroxylase; |
| 基因名称 | TPH1 |
| 蛋白名称 | TPH1 |
| 推荐应用 | |
| 反应物种 | Human(WB);Human Mouse Rat(IHC) |
| 存储缓冲液 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Human Gene Link | 7166 |
| Human Swissprot No. | P17752 |
| Mouse Gene ID | 21990 |
| Mouse Swissprot No. | P17532 |
| Rat Gene ID | 24848 |
| Rat Swissprot No. | P09810 |
| 特异性 | Endogenous |
| 稀释度 | IHC 1:100-1:500;WB 1:500~1:2000 |
| 参考分子量 | MW(Observed): 72 kDa |
| 预测分子量 | MW(Calculated): 51 kDa |
| 运输及保存条件 | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 宿主 | Rabbit |
| 同种型 | IgG,Kappa |
| 背景介绍 | Tryptophan hydroxylase (TPH) is the rate-limiting enzyme in the biosynthesis of serotonin by converting tryptophan to 5-hydroxy-L-tryptophan. Two isoforms of TPH exist: TPH-1 is mainly expressed in the periphery, whereas the expression of TPH-2 is restricted to neuronal cells and the central nervous system. Most of the serotonin found throughout the body is synthesized by TPH-1 in enterochromaffin cells of the gastrointestinal tract. Targeted disruption of the tph1 gene results in low levels of circulating and tissue serotonin. |
| 细胞定位 | Cytosol, neuron projection. |
| 纯化 | Protein A |
| Clonality | Monoclonal |
| 修饰类型 | Unmodified |
| 细胞定位 | Cytosol, neuron projection. |
| 组织表达 | Small intestine, Brain, Pancreas, Carcinoid tumor, Neuroendocrine tumor, Pancreatic carcinoma |
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