| 别名 | RPS3; 40S ribosomal protein S3; |
| 基因名称 | RPS3 |
| 蛋白名称 | RPS3 |
| 推荐应用 | |
| 反应物种 | Human Mouse Rat |
| 存储缓冲液 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Human Gene Link | 6188; |
| Human Swissprot No. | P23396 |
| Mouse Gene ID | 27050; |
| Mouse Swissprot No. | P62908 |
| Rat Gene ID | 140654; |
| Rat Swissprot No. | P62909; |
| 特异性 | Endogenous |
| 稀释度 | IHC 1:100-1:500;WB 1:500~1:2000 |
| 参考分子量 | MW(Observed): 27 kDa |
| 预测分子量 | MW(Calculated): 27 kDa |
| 运输及保存条件 | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 宿主 | Rabbit |
| 同种型 | IgG,Kappa |
| 背景介绍 | Involved in translation as a component of the 40S small ribosomal subunit. Has endonuclease activity and plays a role in repair of damaged DNA. Cleaves phosphodiester bonds of DNAs containing altered bases with broad specificity and cleaves supercoiled DNA more efficiently than relaxed DNA. Displays high binding affinity for 7,8-dihydro-8-oxoguanine (8-oxoG), a common DNA lesion caused by reactive oxygen species (ROS). Has also been shown to bind with similar affinity to intact and damaged DNA. |
| 细胞定位 | Cytoplasm . Nucleus . Nucleus , nucleolus . Mitochondrion inner membrane ; Peripheral membrane protein . Cytoplasm , cytoskeleton , spindle . In normal cells , located mainly in the cytoplasm with small amounts in the nucleus but translocates to the nucleus in cells undergoing apoptosis (By similarity) . Nuclear translocation is induced by DNA damaging agents such as hydrogen peroxide (PubMed:17560175) . Accumulates in the mitochondrion in response to increased ROS levels (PubMed:23911537) . Localizes to the spindle during mitosis (PubMed:23131551) . Localized in cytoplasmic mRNP granules containing untranslated mRNAs (PubMed:17289661) . |
| 纯化 | Protein A |
| Clonality | Monoclonal |
| 修饰类型 | Unmodified |
| 细胞定位 | Cytoplasm . Nucleus . Nucleus , nucleolus . Mitochondrion inner membrane ; Peripheral membrane protein . Cytoplasm , cytoskeleton , spindle . In normal cells , located mainly in the cytoplasm with small amounts in the nucleus but translocates to the nucleus in cells undergoing apoptosis (By similarity) . Nuclear translocation is induced by DNA damaging agents such as hydrogen peroxide (PubMed:17560175) . Accumulates in the mitochondrion in response to increased ROS levels (PubMed:23911537) . Localizes to the spindle during mitosis (PubMed:23131551) . Localized in cytoplasmic mRNP granules containing untranslated mRNAs (PubMed:17289661) . |
| 组织表达 | Ubiquitous expression |
周一至周日 8:00-18:00
