| 别名 | Interferon regulatory factor 1; IRF1; MAR; |
| 基因名称 | IRF1 |
| 蛋白名称 | IRF1 |
| 推荐应用 | |
| 反应物种 | Human Mouse Rat |
| 存储缓冲液 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Human Gene Link | 3659 |
| Human Swissprot No. | P10914 |
| Mouse Gene ID | 16362 |
| 特异性 | Endogenous |
| 稀释度 | WB 1:500~1:1000 |
| 参考分子量 | MW(Observed): 48 kDa |
| 预测分子量 | MW(Calculated): 37 kDa |
| 运输及保存条件 | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 宿主 | Rabbit |
| 同种型 | IgG,Kappa |
| 背景介绍 | Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)) and activates those genes. Acts as a tumor suppressor. Defects in IRF1 are a cause of gastric cancer (GASC) [MIM:613659]; also called gastric cancer intestinal or stomach cancer. Gastric cancer is a malignant disease which starts in the stomach, can spread to the esophagus or the small intestine, and can extend through the stomach wall to nearby lymph nodes and organs. It also can metastasize to other parts of the body. |
| 细胞定位 | Cytoplasm, Nucleus |
| 纯化 | Protein A |
| Clonality | Monoclonal |
| 修饰类型 | Unmodified |
| 细胞定位 | Cytoplasm, Nucleus |
| 组织表达 | Spleen, Lymph node, Thymus, Lymphoma, Inflammatory tissues, Lung cancer. |
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