| 别名 | HD 6; HDAC 6; Histone deacetylase 6 (HD6); JM 21; |
| 基因名称 | HDAC6 |
| 蛋白名称 | HDAC6 |
| 推荐应用 | |
| 反应物种 | Human |
| 存储缓冲液 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Human Gene Link | 10013 |
| Human Swissprot No. | Q9UBN7 |
| Mouse Gene ID | 15185 |
| Mouse Swissprot No. | Q9Z2V5 |
| 特异性 | Endogenous |
| 稀释度 | IHC 1:100-1:500;WB 1:5000~1:20000 |
| 参考分子量 | MW(Observed):160kDa |
| 预测分子量 | MW(Calculated):131kDa |
| 运输及保存条件 | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 宿主 | Rabbit |
| 同种型 | IgG,Kappa |
| 背景介绍 | Involved in the regulation of many cellular processes, including cell migration, immune synapse formation, viral infection, and degradation of misfolded proteins. HDAC6 binds to both poly-ubiquitinated misfolded proteins and dynein motors, facilitating the transport of misfolded proteins to the aggresome. Required for subsequent recruitment of the autophagic machinery and clearance of aggresomes from the cell. Plays a key role in the protection against the deleterious effects of pathological protein aggregation that occurs in various diseases. |
| 细胞定位 | Cell projection, Cytoplasm, Cytoskeleton, Nucleus. |
| 纯化 | Protein A |
| Clonality | Monoclonal |
| 修饰类型 | Unmodified |
| 细胞定位 | Cell projection, Cytoplasm, Cytoskeleton, Nucleus. |
| 组织表达 | Ubiquitous expression |
周一至周日 8:00-18:00
