| 别名 | TCF7L2; HMG box transcription factor 4; HTCF-4; T-cell factor-4 variant X2; T-cell factor 4; Transcription factor 7-like 2; TCF-4; |
| 基因名称 | TCF7L2 |
| 蛋白名称 | TCF7L2 |
| 推荐应用 | |
| 反应物种 | Human Mouse Rat |
| 存储缓冲液 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Human Gene Link | 6934 |
| Human Swissprot No. | Q9NQB0 |
| Mouse Gene ID | 21416 |
| Mouse Swissprot No. | Q924A0 |
| 特异性 | Endogenous |
| 稀释度 | IHC 1:100-1:500;WB 1:5000~1:20000 |
| 参考分子量 | MW(Observed):68kD |
| 预测分子量 | MW(Calculated):68 kD |
| 运输及保存条件 | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 宿主 | Rabbit |
| 同种型 | IgG,Kappa |
| 背景介绍 | Participates in the Wnt signaling pathway and modulates MYC expression by binding to its promoter in a sequence-specific manner. Acts as repressor in the absence of CTNNB1, and as activator in its presence. Activates transcription from promoters with several copies of the Tcf motif 5'-CCTTTGATC-3' in the presence of CTNNB1. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7L2/TCF4 and CTNNB1. |
| 细胞定位 | Nucleus, PML body |
| 纯化 | Protein A |
| Clonality | Monoclonal |
| 修饰类型 | Unmodified |
| 细胞定位 | Nucleus, PML body |
| 组织表达 | Pancreas, Intestine, Liver, Pancreatic cancer, Colon cancer, Hepatocellular carcinoma, Lung cancer. |
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