| 别名 | Adapter molecule crk; avian sarcoma virus CT10 (v-crk) oncogene homolog; CRK; CRKII; Proto-oncogene c-Crk; |
| 基因名称 | Phospho-CrkII (Tyr221) |
| 蛋白名称 | Phospho-CrkII (Tyr221) |
| 推荐应用 | |
| 反应物种 | Human |
| 存储缓冲液 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Human Gene Link | 1398 |
| Human Swissprot No. | P46108 |
| Mouse Gene ID | 12928 |
| Mouse Swissprot No. | Q64010 |
| Rat Gene ID | 54245 |
| Rat Swissprot No. | Q63768 |
| 特异性 | Endogenous |
| 稀释度 | WB 1:1000~1:2000 |
| 参考分子量 | MW(Observed):42kD |
| 预测分子量 | MW(Calculated):34kD |
| 运输及保存条件 | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 宿主 | Rabbit |
| 同种型 | IgG,Kappa |
| 背景介绍 | The Crk-I and Crk-II forms differ in their biological activities. Crk-II has less transforming activity than Crk-I. Crk-II mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3 signaling. |
| 细胞定位 | Cell membrane. Cytoplasm. |
| 纯化 | Protein A |
| Clonality | Monoclonal |
| 修饰类型 | Phospho |
| 细胞定位 | Cell membrane. Cytoplasm. |
| 组织表达 | Widely expressed (Brain, Liver, Lung) |
周一至周日 8:00-18:00
