| 别名 | MAPT; Microtubule-associated protein tau; MTBT1; Neurofibrillary tangle protein; Paired helical filament-tau; PHF-tau; |
| 基因名称 | Phospho-Tau (T231) |
| 蛋白名称 | Phospho-Tau (T231) |
| 推荐应用 | |
| 反应物种 | Human Mouse Rat |
| 存储缓冲液 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Human Gene Link | 4137 |
| Human Swissprot No. | P10636 |
| Mouse Gene ID | 17762 |
| Mouse Swissprot No. | P10637 |
| Rat Swissprot No. | P19332 |
| 特异性 | Endogenous |
| 稀释度 | WB 1:500~1:2000 |
| 参考分子量 | MW(Observed):46kD |
| 预测分子量 | MW(Calculated):79kD |
| 运输及保存条件 | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 宿主 | Rabbit |
| 同种型 | IgG,Kappa |
| 背景介绍 | Tau is a heterogeneous microtubule-associated protein that promotes and stabilizes microtubule assembly, especially in axons. Six isoforms with different amino-terminal inserts and different numbers of tandem repeats near the carboxy-terminus have been identified, and tau is hyperphosphorylated at approximately 25 sites by ERK, GSK-3 and CDK5. Phosphorylation decreases the ability of tau to bind to microtubules. Neurofibrillary tangles are a major hallmark of Alzheimer's disease and these tangles are bundles of paired helical filaments composed of hyperphosphorylated tau. |
| 细胞定位 | Secreted, cytoskeleton, cell membrane, cytosol, axon, dendrite. |
| 纯化 | Protein A |
| Clonality | Monoclonal |
| 修饰类型 | Phospho |
| 细胞定位 | Secreted, cytoskeleton, cell membrane, cytosol, axon, dendrite. |
| 组织表达 | Brain, Spinal cord, Alzheimer's disease brain, Glioma, Neuroblastoma, Lung cancer. |
周一至周日 8:00-18:00
