| 别名 | ESR1; Era; Eralpha; Estrogen receptor; Estradiol receptor; ER-alpha; Estrogen receptor 1; NR3A1; ER; ESR; ESRA; Estrogen receptor alpha; |
| 基因名称 | Phospho-ER alpha (S118) |
| 蛋白名称 | Phospho-ER alpha (S118) |
| 推荐应用 | |
| 反应物种 | Human |
| 存储缓冲液 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Human Gene Link | 2099 |
| Human Swissprot No. | P03372 |
| Mouse Gene ID | 13982 |
| Mouse Swissprot No. | P19785 |
| Rat Gene ID | 24890 |
| Rat Swissprot No. | P06211 |
| 特异性 | Endogenous |
| 稀释度 | IHC 1:100-1:500;WB 1:500~1:2000 |
| 参考分子量 | MW(Observed):66kD |
| 预测分子量 | MW(Calculated):66kD |
| 运输及保存条件 | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 宿主 | Rabbit |
| 同种型 | IgG,Kappa |
| 背景介绍 | Estrogen receptor α (ERα), a member of the steroid receptor superfamily, contains highly conserved DNA binding (DBD) and ligand binding domains (LBD). Through its estrogen-independent and estrogen-dependent activation domains (AF-1 and AF-2, respectively), ERα regulates transcription by recruiting coactivator proteins and interacting with general transcriptional machinery. Phosphorylation provides an important mechanism to regulate ERα activity. ERα is phosphorylated on multiple sites. |
| 细胞定位 | Nucleus, Cytoplasm, Cell membrane. |
| 纯化 | Protein A |
| Clonality | Monoclonal |
| 修饰类型 | Phospho |
| 细胞定位 | Nucleus, Cytoplasm, Cell membrane. |
| 组织表达 | Breast, Uterus, Ovary, Breast cancer, Endometrial cancer, Ovarian cancer, Lung cancer. |
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