| 别名 | NTRK2; gp145-TrkB; Trk-B; TRKB; Tropomyosin-related kinase B; TrkB tyrosine kinase; Tyrosine kinase receptor B; |
| 基因名称 | Phospho-TrkB (Y817) |
| 蛋白名称 | Phospho-TrkB (Y817) |
| 推荐应用 | |
| 反应物种 | Human Mouse Rat |
| 存储缓冲液 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Human Gene Link | 4915 |
| Human Swissprot No. | Q16620 |
| Mouse Gene ID | 18212 |
| Mouse Swissprot No. | P15209 |
| Rat Gene ID | 25054 |
| Rat Swissprot No. | Q63604 |
| 特异性 | Endogenous |
| 稀释度 | IHC 1:100-1:500;WB 1:500~1:1000 |
| 参考分子量 | MW(Observed):140kD |
| 预测分子量 | MW(Calculated):92kD |
| 运输及保存条件 | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 宿主 | Rabbit |
| 同种型 | IgG,Kappa |
| 背景介绍 | The family of Trk receptor tyrosine kinases consists of TrkA, TrkB and TrkC. While the sequence of these family members is highly conserved, they are activated by different neurotrophins: TrkA by NGF, TrkB by BDNF or NT4, and TrkC by NT3. TrkA regulates proliferation and is important for development and maturation of the nervous system. Point mutations, deletions and chromosomal rearrangements (chimeras) cause ligand-independent receptor dimerization and activation of TrkA. |
| 细胞定位 | Cell membrane, Endosome membrane. |
| 纯化 | Protein A |
| Clonality | Monoclonal |
| 修饰类型 | Phospho |
| 细胞定位 | Cell membrane, Endosome membrane. |
| 组织表达 | Brain, Spinal cord, Retina, Glioma, Neuroblastoma, Medulloblastoma, Lung cancer. |
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