| 别名 | KMLS; KRP; MLCK; MYLK; myosin light chain kinase, smooth muscle and non-muscle isozymes; myosin light polypeptide kinase; telokin; |
| 基因名称 | Myosin light chain kinase |
| 蛋白名称 | Myosin light chain kinase |
| 推荐应用 | |
| 反应物种 | Human Mouse Rat |
| 存储缓冲液 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Human Gene Link | 4638 |
| Human Swissprot No. | Q15746 |
| Mouse Swissprot No. | Q6PDN3 |
| 特异性 | Endogenous |
| 稀释度 | IHC 1:100-1:500;WB 1:500~1:2000 |
| 参考分子量 | MW(Observed):200kD |
| 预测分子量 | MW(Calculated):211kD |
| 运输及保存条件 | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 宿主 | Rabbit |
| 同种型 | IgG,Kappa |
| 背景介绍 | Regulates actin-myosin interaction through a non-kinase activity. Phosphorylates PTK2B/PYK2 and myosin light-chains. Involved in the inflammatory response (e.g. apoptosis, vascular permeability, leukocyte diapedesis), cell motility and morphology, airway hyperreactivity and other activities relevant to asthma. Required for tonic airway smooth muscle contraction that is necessary for physiological and asthmatic airway resistance. |
| 细胞定位 | Cytoplasm, Cell projection, Cleavage furrow |
| 纯化 | Protein A |
| Clonality | Monoclonal |
| 修饰类型 | Unmodified |
| 细胞定位 | Cytoplasm, Cell projection, Cleavage furrow |
| 组织表达 | Smooth muscle, Skeletal muscle, Heart, Leiomyosarcoma, Rhabdomyosarcoma, Cardiac sarcoma, Breast cancer. |
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