| 别名 | FEX; GPR49; GPR67; GRP49; LGR5; HG38;8 |
| 基因名称 | LGR5/GPR49 |
| 蛋白名称 | LGR5/GPR49 |
| 推荐应用 | |
| 反应物种 | Mouse Rat |
| 存储缓冲液 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Human Gene Link | 8549 |
| Human Swissprot No. | O75473 |
| Mouse Swissprot No. | Q9Z1P4 |
| 特异性 | Endogenous |
| 稀释度 | WB 1:500~1:2000 |
| 参考分子量 | MW(Observed):100kD |
| 预测分子量 | MW(Calculated):100kD |
| 运输及保存条件 | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 宿主 | Rabbit |
| 同种型 | IgG,Kappa |
| 背景介绍 | Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a stem cell marker of the intestinal epithelium and the hair follicle. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. |
| 细胞定位 | Cell membrane, Golgi apparatus, Membrane. |
| 纯化 | Protein A |
| Clonality | Monoclonal |
| 修饰类型 | Unmodified |
| 细胞定位 | Cell membrane, Golgi apparatus, Membrane. |
| 组织表达 | Small intestine, Colon, Stomach, Colon cancer, Gastric cancer, Liver cancer, Ovarian cancer. |
周一至周日 8:00-18:00
