| 别名 | NOTC1, NOTCH1, TAN1, hN1, neurogenic locus notch homolog protein 1, neurogenic locus notch homolog protein 1 precursor, |
| 基因名称 | Notch1 |
| 蛋白名称 | Notch1 |
| 推荐应用 | |
| 反应物种 | Human Mouse |
| 存储缓冲液 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Human Gene Link | 4851 |
| Human Swissprot No. | P46531 |
| Mouse Gene ID | 18128 |
| Mouse Swissprot No. | Q01705 |
| Rat Swissprot No. | Q07008 |
| 特异性 | Endogenous |
| 稀释度 | IHC 1:100-1:500;WB 1:500~1:3000 |
| 参考分子量 | MW(Observed):125kD |
| 预测分子量 | MW(Calculated):273kD |
| 运输及保存条件 | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 宿主 | Rabbit |
| 同种型 | IgG,Kappa |
| 背景介绍 | Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. |
| 细胞定位 | Cell membrane, Late endosome membrane; Nucleus (intracellular domain). |
| 纯化 | Protein A |
| Clonality | Monoclonal |
| 修饰类型 | Unmodified |
| 细胞定位 | Cell membrane, Late endosome membrane; Nucleus (intracellular domain). |
| 组织表达 | Widely expressed (Brain, Lung, Kidney) |
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