| 别名 | Sequestosome-1;EBI3-associated protein of 60 kDa;EBIAP;p60;Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa;Ubiquitin-binding protein p62; |
| 基因名称 | SQSTM1/p62 |
| 蛋白名称 | SQSTM1/p62 (Ser349) |
| 推荐应用 | |
| 反应物种 | Human,Mouse,Rat |
| 存储缓冲液 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Human Gene Link | 8878 |
| Human Swissprot No. | Q13501 |
| 特异性 | endogenous |
| 稀释度 | WB 1:2000-1:10000;IF 1:50-1:200;ELISA 1:5000-1:20000; |
| 参考分子量 | MW(Observed):62kD |
| 预测分子量 | MW(Calculated):48kD |
| 运输及保存条件 | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 宿主 | Rabbit |
| 同种型 | IgG,Kappa |
| 背景介绍 | This gene encodes a multifunctional protein that binds ubiquitin and regulates activation of the nuclear factor kappa-B (NF-kB) signaling pathway. The protein functions as a scaffolding/adaptor protein in concert with TNF receptor-associated factor 6 to mediate activation of NF-kB in response to upstream signals. Alternatively spliced transcript variants encoding either the same or different isoforms have been identified for this gene. Mutations in this gene result in sporadic and familial Paget disease of bone. [provided by RefSeq, Mar 2009], |
| 细胞定位 | Cytoplasm, Endoplasmic reticulum, Endosome, Lysosome, Nucleus. |
| 纯化 | Protein A |
| Clonality | Monoclonal |
| 修饰类型 | Phospho |
| 细胞定位 | Cytoplasm, Endoplasmic reticulum, Endosome, Lysosome, Nucleus. |
| 组织表达 | Liver, Kidney, Brain, Hepatocellular carcinoma, Lung cancer, Colon cancer, Breast cancer |
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