| 别名 | Alpha fetoglobulin; Alpha fetoprotein precursor; FETA; HPAFP; |
| 基因名称 | AFP |
| 蛋白名称 | AFP |
| 推荐应用 | |
| 反应物种 | Human |
| 存储缓冲液 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Human Gene Link | 174 |
| Human Swissprot No. | P02771 |
| Mouse Gene ID | 11576 |
| Mouse Swissprot No. | P02772 |
| Rat Swissprot No. | P02773 |
| 特异性 | Endogenous |
| 稀释度 | WB 1:500~1:2000 IHC 1:50~1:200 ICC/IF 1:50~1:200 IP 1:50 FC 1:50 |
| 参考分子量 | MW(Observed):68kD |
| 预测分子量 | MW(Calculated):69kD |
| 运输及保存条件 | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 宿主 | Rabbit |
| 同种型 | IgG,Kappa |
| 背景介绍 | Alpha-fetoprotein (AFP) is a 65 kDa glycoprotein found in the mammalian fetal liver, yolk sac, and GI tract. In normal adult cells, p53 binds to the repressor region of the AFP gene, thereby blocking transcription. Mutations in both p53 and β-catenin are associated with aberrant expression of AFP. Research studies have shown that elevated serum AFP levels are predictive of hepatocellular carcinoma . |
| 细胞定位 | Secreted. |
| 纯化 | Protein A |
| Clonality | Monoclonal |
| 修饰类型 | Unmodified |
| 细胞定位 | Secreted. |
| 组织表达 | Liver, Placenta, Fetal tissue, Hepatocellular carcinoma, Germ cell tumor, Yolk sac tumor, Lung cancer. |
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