| 别名 | APC; APC protein; Adenomatous polyposis coli protein; DP2.5; mAPC; |
| 基因名称 | APC |
| 蛋白名称 | APC |
| 推荐应用 | |
| 反应物种 | Human Rat |
| 存储缓冲液 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Human Gene Link | 324 |
| Human Swissprot No. | P25054 |
| Mouse Swissprot No. | Q61315 |
| Rat Gene ID | 24205 |
| Rat Swissprot No. | P70478 |
| 特异性 | Endogenous |
| 稀释度 | IHC 1:100-1:500;WB 1:500~1:2000 |
| 参考分子量 | MW(Observed):160kD |
| 预测分子量 | MW(Calculated):312kD |
| 运输及保存条件 | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 宿主 | Rabbit |
| 同种型 | IgG,Kappa |
| 背景介绍 | Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. |
| 细胞定位 | Cytoplasm, Cell junction, Cell membrane. |
| 纯化 | Protein A |
| Clonality | Monoclonal |
| 修饰类型 | Unmodified |
| 细胞定位 | Cytoplasm, Cell junction, Cell membrane. |
| 组织表达 | Colon, Small intestine, Liver, Colon cancer, Gastric cancer, Hepatocellular carcinoma, Lung cancer. |
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