| 别名 | ACL; ATPCL; CLATP; ATP citrate lyase; |
| 基因名称 | ATP citrate lyase |
| 蛋白名称 | ATP citrate lyase |
| 推荐应用 | |
| 反应物种 | Human Mouse Rat |
| 存储缓冲液 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Human Gene Link | 47 |
| Human Swissprot No. | P53396 |
| Mouse Gene ID | 104112 |
| Mouse Swissprot No. | Q91V92 |
| Rat Gene ID | 24159 |
| Rat Swissprot No. | P16638 |
| 特异性 | Endogenous |
| 稀释度 | IHC 1:100-1:500;WB 1:500~1:2000 |
| 参考分子量 | MW(Observed):122kD |
| 预测分子量 | MW(Calculated):121kD |
| 运输及保存条件 | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 宿主 | Rabbit |
| 同种型 | IgG,Kappa |
| 背景介绍 | ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is a tetramer (relative molecular weight approximately 440,000) of apparently identical subunits. It catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and CoA with a concomitant hydrolysis of ATP to ADP and phosphate. The product, acetyl-CoA, serves several important biosynthetic pathways, including lipogenesis and cholesterogenesis. |
| 细胞定位 | Cytoplasm, cytosol. |
| 纯化 | Protein A |
| Clonality | Monoclonal |
| 修饰类型 | Unmodified |
| 细胞定位 | Cytoplasm, cytosol. |
| 组织表达 | Liver, Adipose tissue, Kidney, Hepatocellular carcinoma, Renal cell carcinoma, Breast cancer, Lung cancer. |
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