| 别名 | Mixed lineage kinase domain-like protein; hMLKL; |
| 基因名称 | MLKL |
| 蛋白名称 | MLKL |
| 推荐应用 | |
| 反应物种 | Human |
| 存储缓冲液 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Human Gene Link | 197259 |
| Human Swissprot No. | Q8NB16 |
| Mouse Swissprot No. | Q9D2Y4 |
| 特异性 | Endogenous |
| 稀释度 | IHC 1:100-1:500;WB 1:500~1:2000 |
| 参考分子量 | MW(Observed):54kD |
| 预测分子量 | MW(Calculated):54kD |
| 运输及保存条件 | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 宿主 | Rabbit |
| 同种型 | IgG,Kappa |
| 背景介绍 | Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process. Activated following phosphorylation by RIPK3, leading to homotrimerization, localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage. Does not have protein kinase activity. |
| 细胞定位 | Cytoplasm, Cell membrane, Nucleus. |
| 纯化 | Protein A |
| Clonality | Monoclonal |
| 修饰类型 | Unmodified |
| 细胞定位 | Cytoplasm, Cell membrane, Nucleus. |
| 组织表达 | Widely expressed (Spleen, Liver, Lung) |
周一至周日 8:00-18:00
