| 别名 | CD141; Fetomodulin; THBD; THRM; thrombomodulin; TM; |
| 基因名称 | Thrombomodulin |
| 蛋白名称 | Thrombomodulin |
| 推荐应用 | |
| 反应物种 | Human |
| 存储缓冲液 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Human Gene Link | 7056 |
| Human Swissprot No. | P07204 |
| Mouse Swissprot No. | P15306 |
| 特异性 | Endogenous |
| 稀释度 | IHC 1:100-1:500;WB 1:500~1:2000 |
| 参考分子量 | MW(Observed):60kD |
| 预测分子量 | MW(Calculated):60kD |
| 运输及保存条件 | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 宿主 | Rabbit |
| 同种型 | IgG,Kappa |
| 背景介绍 | Thrombomodulin (TM), also called CD141, is a type I membrane receptor that is specific to endothelial cells. TM has a cysteine-rich extracellular domain with six EGF-like regions. It forms a complex with Thrombin, which activates Protein C to generate activated Protein C (APC), an anticoagulant enzyme. APC together with Protein S inhibits coagulation by inactivating Factors Va and VIIIa. Deletion of the TM gene results in embryonic lethality in mice. |
| 细胞定位 | Membrane. |
| 纯化 | Protein A |
| Clonality | Monoclonal |
| 修饰类型 | Unmodified |
| 细胞定位 | Membrane. |
| 组织表达 | Vascular endothelium, Lung, Kidney, Angiosarcoma, Lung cancer, Renal cell carcinoma, Breast cancer. |
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