| 别名 | 4E-BP1; 4EBP1; BP-1; MGC4316; PHAS-I; |
| 基因名称 | eIF4EBP1 |
| 蛋白名称 | eIF4EBP1 |
| 推荐应用 | |
| 反应物种 | Human Mouse Rat |
| 存储缓冲液 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Human Gene Link | 1978 |
| Human Swissprot No. | Q13541 |
| Mouse Gene ID | 13685 |
| Mouse Swissprot No. | Q60876 |
| Rat Gene ID | 116636 |
| Rat Swissprot No. | Q62622 |
| 特异性 | Endogenous |
| 稀释度 | WB 1:1000~1:2000 |
| 参考分子量 | MW(Observed):18kD |
| 预测分子量 | MW(Calculated):13kD |
| 运输及保存条件 | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 宿主 | Rabbit |
| 同种型 | IgG,Kappa |
| 背景介绍 | Translation repressor protein 4E-BP1 (also known as PHAS-1) inhibits cap-dependent translation by binding to the translation initiation factor eIF4E. Hyperphosphorylation of 4E-BP1 disrupts this interaction and results in activation of cap-dependent translation. Both the PI3 kinase/Akt pathway and FRAP/mTOR kinase regulate 4E-BP1 activity. |
| 细胞定位 | Cytoplasm, cytosol. |
| 纯化 | Protein A |
| Clonality | Monoclonal |
| 修饰类型 | Unmodified |
| 细胞定位 | Cytoplasm, cytosol. |
| 组织表达 | Widely expressed (Liver, Kidney, Lung) |
周一至周日 8:00-18:00
