| 别名 | Integrin alpha-5; VLA-5; CD49e; ITGA5; FNRA; |
| 基因名称 | Integrin alpha 5 |
| 蛋白名称 | Integrin alpha 5 |
| 推荐应用 | |
| 反应物种 | Human Mouse Rat |
| 存储缓冲液 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Human Gene Link | 3678 |
| Human Swissprot No. | P08648 |
| Mouse Gene ID | 16402 |
| Mouse Swissprot No. | P11688 |
| 特异性 | Endogenous |
| 稀释度 | WB 1:1000~1:2000 |
| 参考分子量 | MW(Observed):150kD |
| 预测分子量 | MW(Calculated):115kD |
| 运输及保存条件 | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 宿主 | Rabbit |
| 同种型 | IgG,Kappa |
| 背景介绍 | Integrin alpha-5/beta-1 is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. ITGA5:ITGB1 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1. ITGA5:ITGB1 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1. |
| 细胞定位 | Membrane, Cell junction, Cell surface. |
| 纯化 | Protein A |
| Clonality | Monoclonal |
| 修饰类型 | Unmodified |
| 细胞定位 | Membrane, Cell junction, Cell surface. |
| 组织表达 | Widely expressed (Epithelium, Endothelium, Liver) |
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