| 别名 | AKT 1; PKB; PKB-ALPHA; PRKBA; Protein Kinase B Alpha; Protein kinase B; Proto-oncogene c-Akt; RAC Alpha; RAC-alpha serine/threonine-protein kinase; RAC-PK-alpha; |
| 基因名称 | Phospho-AKT1 (T450) |
| 蛋白名称 | Phospho-AKT1 (T450) |
| 推荐应用 | |
| 反应物种 | Human,Mouse,Rat |
| 存储缓冲液 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Human Gene Link | 207 |
| Human Swissprot No. | P31749 |
| Mouse Gene ID | 11651 |
| Mouse Swissprot No. | P31750 |
| Rat Gene ID | 24185 |
| Rat Swissprot No. | P47196 |
| 特异性 | Endogenous |
| 稀释度 | WB 1:1000~1:2000 |
| 参考分子量 | MW(Observed):60kD |
| 预测分子量 | MW(Calculated):56kD |
| 运输及保存条件 | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 宿主 | Rabbit |
| 同种型 | IgG,Kappa |
| 背景介绍 | Akt, also referred to as PKB or Rac, plays a critical role in controlling survival and apoptosis. This protein kinase is activated by insulin and various growth and survival factors to function in a wortmannin-sensitive pathway involving PI3 kinase. Akt is activated by phospholipid binding and activation loop phosphorylation at Thr308 by PDK1 and by phosphorylation within the carboxy terminus at Ser473. |
| 细胞定位 | Cytoplasm, Nucleus, Cell membrane. |
| 纯化 | Protein A |
| Clonality | Monoclonal |
| 修饰类型 | Phospho |
| 细胞定位 | Cytoplasm, Nucleus, Cell membrane. |
| 组织表达 | Widely expressed (Liver, Kidney, Lung) |
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