| 别名 | ERK-1; ERK1; ERT2; kinase ERK1; MAP kinase 1; MAPK 1; MAPK3; MK03; MNK1; p44-ERK1; P44-ERK1; p44-MAPK; |
| 基因名称 | Phospho-Erk1 (T202/Y204) + Erk2 (T185/Y187) |
| 蛋白名称 | Phospho-Erk1 (T202/Y204) + Erk2 (T185/Y187) |
| 推荐应用 | |
| 反应物种 | Human,Mouse,Rat |
| 存储缓冲液 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Human Gene Link | 5594;5595 |
| Human Swissprot No. | P27361;P28482 |
| Mouse Gene ID | 26417;26413 |
| Rat Gene ID | 50689;116590 |
| Rat Swissprot No. | P21708;P63086 |
| 特异性 | Endogenous |
| 稀释度 | WB 1:500~1:2000 |
| 参考分子量 | MW(Observed):42kD |
| 预测分子量 | MW(Calculated):42kD/44kD |
| 运输及保存条件 | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 宿主 | Rabbit |
| 同种型 | IgG,Kappa |
| 背景介绍 | Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. |
| 细胞定位 | caveola, cytoplasm, cytoskeleton, cytosol, early endosome, endoplasmic reticulum lumen, focal adhesion, Golgi apparatus, late endosome, mitochondrion, nuclear envelope, nucleoplasm, nucleus, plasma membrane. |
| 纯化 | Protein A |
| Clonality | Monoclonal |
| 修饰类型 | Phospho |
| 细胞定位 | caveola, cytoplasm, cytoskeleton, cytosol, early endosome, endoplasmic reticulum lumen, focal adhesion, Golgi apparatus, late endosome, mitochondrion, nuclear envelope, nucleoplasm, nucleus, plasma membrane. |
| 组织表达 | Widely expressed (Brain, Liver, Lung) |
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