| 别名 | TOR1A;DQ2; DYT1; TorsinA; |
| 基因名称 | Torsin A |
| 蛋白名称 | Torsin A |
| 推荐应用 | |
| 反应物种 | Human |
| 存储缓冲液 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Human Gene Link | 1861 |
| Human Swissprot No. | O14656 |
| Mouse Gene ID | 30931 |
| Mouse Swissprot No. | Q9ER39 |
| 特异性 | Endogenous |
| 稀释度 | WB 1:500~1:2000 |
| 参考分子量 | MW(Observed):35kD |
| 预测分子量 | MW(Calculated):38kD |
| 运输及保存条件 | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 宿主 | Rabbit |
| 同种型 | IgG,Kappa |
| 背景介绍 | The neurological condition Dystonia is associated with sustained muscle contractions and abnormal posturing. TorsinA, torsinB, torp2A and torp3A belong to the family of ATPases associated with cellular activites (AAA+) and mutations in torsinA cause early onset dystonia. TorsinA has been shown to suppress intracellular protein aggregation in C. elegans and possesses chaperon activity. Interestingly, torsinA is highly expressed in dopaminergic neurons and associates with alpha-synuclein in Lewy bodies, which pathologically characterize Parkinson's Disease. |
| 细胞定位 | Cell projection, Cytoplasm, Cytoplasmic vesicle, Cytoplasmic vesicle membrane, Endoplasmic reticulum lumen, Nucleus membrane, Peripheral membrane protein, cytoskeleton, growth cone, secretory vesicle, synaptic vesicle. |
| 纯化 | Protein A |
| Clonality | Monoclonal |
| 修饰类型 | Unmodified |
| 细胞定位 | Cell projection, Cytoplasm, Cytoplasmic vesicle, Cytoplasmic vesicle membrane, Endoplasmic reticulum lumen, Nucleus membrane, Peripheral membrane protein, cytoskeleton, growth cone, secretory vesicle, synaptic vesicle. |
| 组织表达 | Brain, Liver, Kidney, Glioma, Hepatocellular carcinoma, Lung cancer. |
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