| 别名 | Complement component C9; Comple Complement component C9bment component C9a; |
| 基因名称 | C9 |
| 蛋白名称 | C9 |
| 推荐应用 | |
| 反应物种 | Human |
| 存储缓冲液 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Human Gene Link | 735 |
| Human Swissprot No. | P02748 |
| Mouse Swissprot No. | P06683 |
| 特异性 | Endogenous |
| 稀释度 | WB 1:500~1:2000 |
| 参考分子量 | MW(Observed):70kD |
| 预测分子量 | MW(Calculated):71kD |
| 运输及保存条件 | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 宿主 | Rabbit |
| 同种型 | IgG,Kappa |
| 背景介绍 | C9 is synthesised in the liver and monocytes, and is a plasma protein consisting of a single polypeptide chain of molecular weight 71kDa. Normal plasma concentration is 60mg/L. C9 forms part of the membrane attack complex (MAC) the cytolytic terminal complex of the complement pathways. C9 binds to the membrane associated C5b-8, binding of C9 to C5b-8 leads to the circular polymerisation of 12-18 C9 molecules. This is the basis of the hydrophilic, protein-walled, trans-membrane channel formed by the MAC, which leads to cell lysis and destruction. |
| 细胞定位 | Cell membrane, Multi-pass membrane protein, Secreted. |
| 纯化 | Protein A |
| Clonality | Monoclonal |
| 修饰类型 | Unmodified |
| 细胞定位 | Cell membrane, Multi-pass membrane protein, Secreted. |
| 组织表达 | Liver, Spleen, Kidney, Hepatocellular carcinoma, Lymphoma, Renal cell carcinoma. |
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