| 别名 | DNA- PKcs, DNA-dependent protein kinase catalytic subunit, DNPK1, EC 2.7.11.1, P460, PRKD, PRKDC, XRCC7, kinase DNA-PK |
| 基因名称 | Phospho-DNA PKcs (S2056) |
| 蛋白名称 | Phospho-DNA PKcs (S2056) |
| 推荐应用 | |
| 反应物种 | Human |
| 存储缓冲液 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Human Gene Link | 5591 |
| Human Swissprot No. | P78527 |
| Mouse Gene ID | 19090 |
| Mouse Swissprot No. | P97313 |
| 特异性 | Endogenous |
| 稀释度 | WB 1:500~1:2000 |
| 参考分子量 | MW(Observed):469kD |
| 预测分子量 | MW(Calculated):469kD |
| 运输及保存条件 | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 宿主 | Rabbit |
| 同种型 | IgG,Kappa |
| 背景介绍 | The PRKDC gene encodes the catalytic subunit of a nuclear DNA-dependent serine/threonine protein kinase (DNA-PK). The second component is the autoimmune antigen Ku (MIM 152690), which is encoded by the G22P1 gene on chromosome 22q. On its own, the catalytic subunit of DNA-PK is inactive and relies on the G22P1 component to direct it to the DNA and trigger its kinase activity; PRKDC must be bound to DNA to express its catalytic properties. |
| 细胞定位 | Nucleus, nucleolus. |
| 纯化 | Protein A |
| Clonality | Monoclonal |
| 修饰类型 | Phospho |
| 细胞定位 | Nucleus, nucleolus. |
| 组织表达 | Widely expressed (Testis, Thymus, Bone marrow) |
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