| 别名 | Cellular tumor antigen p53; Phosphoprotein p53; TP53; Tumor suppressor p53; |
| 基因名称 | p53 |
| 蛋白名称 | p53 |
| 推荐应用 | |
| 反应物种 | Human |
| 存储缓冲液 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Human Gene Link | 7157 |
| Human Swissprot No. | P04637 |
| Mouse Gene ID | 22059 |
| Mouse Swissprot No. | P02340 |
| Rat Gene ID | 24842 |
| Rat Swissprot No. | P10361 |
| 特异性 | Endogenous |
| 稀释度 | WB 1:500~1:2000 |
| 参考分子量 | MW(Observed):53kD |
| 预测分子量 | MW(Calculated):44kD |
| 运输及保存条件 | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 宿主 | Rabbit |
| 同种型 | IgG,Kappa |
| 背景介绍 | Plays an essential role in the regulation of cell cycle, specifically in the transition from G0 to G1. p53 is a DNA-binding protein containing DNA-binding, oligomerization and transcription activation domains. It is postulated to bind as a tetramer to a p53-binding site and activate expression of downstream genes that inhibit growth and/or invasion, and thus function as a tumor suppressor. |
| 细胞定位 | Cytoplasm, Nucleus, PML body, Endoplasmicreticulum, Mitochondrionmatrix, Cytoplasm, cytoskeleton, microtubule organizing center, centrosome |
| 纯化 | Protein A |
| Clonality | Monoclonal |
| 修饰类型 | Unmodified |
| 细胞定位 | Cytoplasm, Nucleus, PML body, Endoplasmicreticulum, Mitochondrionmatrix, Cytoplasm, cytoskeleton, microtubule organizing center, centrosome |
| 组织表达 | Lung cancer, Breast cancer, Colon cancer, Ovarian cancer, Hepatocellular carcinoma, Glioma. |
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