| 别名 | kinase ATM; Serine-protein kinase ATM |
| 基因名称 | Phospho-ATM (S1981) |
| 蛋白名称 | Phospho-ATM (S1981) |
| 推荐应用 | |
| 反应物种 | Human |
| 存储缓冲液 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Human Gene Link | 472 |
| Human Swissprot No. | Q13315 |
| Mouse Gene ID | 11920 |
| Mouse Swissprot No. | Q62388 |
| 特异性 | Endogenous |
| 稀释度 | WB 1:500~1:2000 |
| 参考分子量 | MW(Observed):370kD |
| 预测分子量 | MW(Calculated):351kD |
| 运输及保存条件 | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 宿主 | Rabbit |
| 同种型 | IgG,Kappa |
| 背景介绍 | The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. |
| 细胞定位 | Cytoplasmic vesicle, Nucleus. |
| 纯化 | Protein A |
| Clonality | Monoclonal |
| 修饰类型 | Phospho |
| 细胞定位 | Cytoplasmic vesicle, Nucleus. |
| 组织表达 | Widely expressed (Testis, Thymus, Bone marrow) |
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