| 别名 | DNA binding protein SATB1; DNA-binding protein SATB1; SATB homeobox 1; |
| 基因名称 | SATB1 |
| 蛋白名称 | SATB1 |
| 推荐应用 | |
| 反应物种 | Human,Mouse |
| 存储缓冲液 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Human Gene Link | 6304 |
| Human Swissprot No. | Q01826 |
| Mouse Gene ID | 20230 |
| Mouse Swissprot No. | Q60611 |
| 特异性 | Endogenous |
| 稀释度 | WB 1:500~1:3000 |
| 参考分子量 | MW(Observed):100kD |
| 预测分子量 | MW(Calculated):86kD |
| 运输及保存条件 | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 宿主 | Rabbit |
| 同种型 | IgG,Kappa |
| 背景介绍 | SATB1 is a crucial silencing factor contributing to the initiation of X inactivation mediated by Xist RNA that occurs during embryogenesis and in lymphoma (By similarity). Binds to DNA at special AT-rich sequences, the consensus SATB1-binding sequence (CSBS), at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcriptional repressor controlling nuclear and viral gene expression in a phosphorylated and acetylated status-dependent manner, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. |
| 细胞定位 | Nucleus. |
| 纯化 | Protein A |
| Clonality | Monoclonal |
| 修饰类型 | Unmodified |
| 细胞定位 | Nucleus. |
| 组织表达 | Thymus, Spleen, Bone marrow, Lymphoma, Leukemia, Lung cancer. |
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