| 别名 | CASP12;Inactive caspase-12;CASP-12 |
| 基因名称 | Caspase-12 |
| 蛋白名称 | caspase12 |
| 推荐应用 | |
| 反应物种 | Human,Mouse,Rat |
| 存储缓冲液 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Human Gene Link | 120329 |
| Human Swissprot No. | Q6UXS9 |
| Mouse Swissprot No. | O08736 |
| 特异性 | endogenous |
| 稀释度 | WB 1:1000-1:4000;IF 1:50-1:200;ELISA 1:5000-1:20000; |
| 参考分子量 | MW(Observed):53kD,43kD |
| 预测分子量 | MW(Calculated):39kD |
| 运输及保存条件 | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 宿主 | Rabbit |
| 同种型 | IgG,Kappa |
| 背景介绍 | Caspases are cysteine proteases that cleave C-terminal aspartic acid residues on their substrate molecules. This gene is most highly related to members of the ICE subfamily of caspases that process inflammatory cytokines. In rodents, the homolog of this gene mediates apoptosis in response to endoplasmic reticulum stress. However, in humans this gene contains a polymorphism for the presence or absence of a premature stop codon. The majority of human individuals have the premature stop codon and produce a truncated non-functional protein. The read-through codon occurs primarily in individuals of African descent and carriers have endotoxin hypo-responsiveness and an increased susceptibility to severe sepsis. Several alternatively spliced transcript variants have been noted for this gene. [provided by RefSeq, Feb 2011], |
| 细胞定位 | endoplasmic reticulum,IPAF inflammasome complex,NLRP3 inflammasome complex,AIM2 inflammasome complex, |
| 功能 | proteolysis, apoptosis, virus-infected cell apoptosis, ER-nuclear signaling pathway, response to unfolded protein, cell death, response to organic substance, regulation of cell death, programmed cell death, death, endoplasmic reticulum unfolded protein response, cellular response to stress, cellular response to unfolded protein, response to endoplasmic reticulum stress, regulation of apoptosis, regulation of programmed cell death, response to protein stimulus,apoptosis in response to endoplasmic reticulum stress, |
| 纯化 | Protein A |
| Clonality | Monoclonal |
| 修饰类型 | Unmodified |
| 细胞定位 | endoplasmic reticulum,IPAF inflammasome complex,NLRP3 inflammasome complex,AIM2 inflammasome complex, |
| 组织表达 | Detected in heart, kidney, liver, lung, pancreas, small intestine, spleen, stomach, thymus and testis. |
| 研究领域 | >>Protein processing in endoplasmic reticulum;>>Apoptosis;>>NOD-like receptor signaling pathway;>>Alzheimer disease;>>Amyotrophic lateral sclerosis;>>Prion disease;>>Pathways of neurodegeneration - multiple diseases;>>Hepatitis B |
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