| 别名 | KRT13;Keratin;type I cytoskeletal 13;Cytokeratin-13;CK-13;Keratin-13;K13 |
| 基因名称 | Cytokeratin 13 |
| 蛋白名称 | Keratin type I cytoskeletal 13 |
| 推荐应用 | |
| 反应物种 | Human,Mouse,Rat |
| 存储缓冲液 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Human Gene Link | 3860 |
| Human Swissprot No. | P13646 |
| Mouse Gene ID | 16663 |
| Mouse Swissprot No. | P08730 |
| Rat Gene ID | 287699 |
| Rat Swissprot No. | Q6IFV4 |
| 特异性 | endogenous |
| 稀释度 | WB 1:1000-1:4000;IF 1:50-1:200;ELISA 1:5000-1:20000; |
| 参考分子量 | MW(Observed):50kD |
| 预测分子量 | MW(Calculated):50kD |
| 运输及保存条件 | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 宿主 | Rabbit |
| 同种型 | IgG,Kappa |
| 背景介绍 | The protein encoded by this gene is a member of the keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Most of the type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. This type I cytokeratin is paired with keratin 4 and expressed in the suprabasal layers of non-cornified stratified epithelia. Mutations in this gene and keratin 4 have been associated with the autosomal dominant disorder White Sponge Nevus. The type I cytokeratins are clustered in a region of chromosome 17q21.2. Alternative splicing of this gene results in multiple transcript variants; however, not all variants have been described. [provided by RefSeq, Jul 2008], |
| 细胞定位 | nucleus,intermediate filament,keratin filament,intermediate filament cytoskeleton,extracellular exosome, |
| 功能 | Disease:Defects in KRT13 are a cause of white sponge nevus of cannon (WSN) [MIM:193900]. WSN is a rare autosomal dominant disorder which predominantly affects non-cornified stratified squamous epithelia. Clinically, it is characterized by the presence of soft, white, and spongy plaques in the oral mucosa. The characteristic histopathologic features are epithelial thickening, parakeratosis, and vacuolization of the suprabasal layer of oral epithelial keratinocytes. Less frequently the mucous membranes of the nose, esophagus, genitalia and rectum are involved.,miscellaneous:There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).,online information:Keratin-13 entry,PTM:O-glycosylated; glycans consist of single N-acetylglucosamine residues.,similarity:Belongs to the intermediate filament family.,subunit:Heterotetramer of two type I and two type II keratins. keratin-13 is generally associated with keratin-4.,tissue specificity:Expressed in some epidermal sweat gland ducts (at protein level) and in exocervix, esophagus and placenta., |
| 纯化 | Protein A |
| Clonality | Monoclonal |
| 修饰类型 | Unmodified |
| 细胞定位 | nucleus,intermediate filament,keratin filament,intermediate filament cytoskeleton,extracellular exosome, |
| 组织表达 | Expressed in some epidermal sweat gland ducts (at protein level) and in exocervix, esophagus and placenta. |
| 研究领域 | >>Estrogen signaling pathway;>>Staphylococcus aureus infection |
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