| 别名 | Cathepsin K;Cathepsin O;Cathepsin O2;Cathepsin X; |
| 基因名称 | CATK |
| 蛋白名称 | CATK |
| 推荐应用 | |
| 反应物种 | Human,Mouse,Rat |
| 存储缓冲液 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Human Gene Link | 1513 |
| Human Swissprot No. | P43235 |
| Mouse Gene ID | 13038 |
| Mouse Swissprot No. | P55097 |
| Rat Gene ID | 29175 |
| Rat Swissprot No. | O35186 |
| 特异性 | endogenous |
| 稀释度 | WB 1:1000-1:4000;IF 1:50-1:200;ELISA 1:5000-1:20000; |
| 参考分子量 | MW(Observed):48kD |
| 预测分子量 | MW(Calculated):37kD |
| 运输及保存条件 | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 宿主 | Rabbit |
| 同种型 | IgG,Kappa |
| 背景介绍 | The protein encoded by this gene is a lysosomal cysteine proteinase involved in bone remodeling and resorption. This protein, which is a member of the peptidase C1 protein family, is predominantly expressed in osteoclasts. However, the encoded protein is also expressed in a significant fraction of human breast cancers, where it could contribute to tumor invasiveness. Mutations in this gene are the cause of pycnodysostosis, an autosomal recessive disease characterized by osteosclerosis and short stature. |
| 细胞定位 | Lysosome . Secreted . Apical cell membrane ; Peripheral membrane protein ; Extracellular side . Localizes to the lumen of thyroid follicles and to the apical membrane of thyroid epithelial cells. . |
| 纯化 | Protein A |
| Clonality | Monoclonal |
| 修饰类型 | Unmodified |
| 细胞定位 | Lysosome . Secreted . Apical cell membrane ; Peripheral membrane protein ; Extracellular side . Localizes to the lumen of thyroid follicles and to the apical membrane of thyroid epithelial cells. . |
| 组织表达 | Predominantly expressed in osteoclasts (bones) (PubMed:7805878). Expressed in thyroid epithelial cells (PubMed:11082042). |
| 研究领域 | >>Lysosome;>>Apoptosis;>>Osteoclast differentiation;>>Toll-like receptor signaling pathway;>>Rheumatoid arthritis |
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