| 别名 | IL1R1;IL1R;IL1RA;IL1RT1;Interleukin-1 receptor type 1;IL-1R-1;IL-1RT-1;IL-1RT1;CD121 antigen-like family member A;Interleukin-1 receptor alpha;IL-1R-alpha;Interleukin-1 receptor type I;p80;CD121a |
| 基因名称 | IL-1RI |
| 蛋白名称 | Interleukin-1 receptor type 1 |
| 推荐应用 | |
| 反应物种 | Mouse,Rat |
| 存储缓冲液 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Human Gene Link | 3554 |
| Human Swissprot No. | P14778 |
| Mouse Swissprot No. | P13504 |
| 特异性 | endogenous |
| 稀释度 | WB 1:1000-1:4000;IF 1:50-1:200;ELISA 1:5000-1:20000; |
| 参考分子量 | MW(Observed):80kD |
| 预测分子量 | MW(Calculated):65kD |
| 运输及保存条件 | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 宿主 | Rabbit |
| 同种型 | IgG,Kappa |
| 背景介绍 | This gene encodes a cytokine receptor that belongs to the interleukin-1 receptor family. The encoded protein is a receptor for interleukin-1 alpha, interleukin-1 beta, and interleukin-1 receptor antagonist. It is an important mediator involved in many cytokine-induced immune and inflammatory responses. This gene is located in a cluster of related cytokine receptor genes on chromosome 2q12. [provided by RefSeq, Dec 2013], |
| 细胞定位 | Membrane ; Single-pass type I membrane protein . Cell membrane . Secreted . |
| 功能 | Function:Receptor for interleukin-1 alpha (IL-1A), beta (IL-1B), and interleukin-1 receptor antagonist protein (IL-1RA). Binding to the agonist leads to the activation of NF-kappa-B. Signaling involves formation of a ternary complex containing IL1RAP, TOLLIP, MYD88, and IRAK1 or IRAK2.,similarity:Belongs to the interleukin-1 receptor family.,similarity:Contains 1 TIR domain.,similarity:Contains 3 Ig-like C2-type (immunoglobulin-like) domains.,subunit:Binds IL1RAP., |
| 纯化 | Protein A |
| Clonality | Monoclonal |
| 修饰类型 | Unmodified |
| 细胞定位 | Membrane ; Single-pass type I membrane protein . Cell membrane . Secreted . |
| 组织表达 | Expressed in T-helper cell subsets. Preferentially expressed in T-helper 1 (Th1) cells. |
| 研究领域 | >>MAPK signaling pathway;>>Cytokine-cytokine receptor interaction;>>NF-kappa B signaling pathway;>>Osteoclast differentiation;>>Hematopoietic cell lineage;>>Th17 cell differentiation;>>Inflammatory mediator regulation of TRP channels;>>Pathogenic Escherichia coli infection;>>Shigellosis;>>Amoebiasis;>>Human cytomegalovirus infection;>>Human T-cell leukemia virus 1 infection;>>Fluid shear stress and atherosclerosis |
周一至周日 8:00-18:00
