| 别名 | GMEB1, 241447C6, DNA-binding protein p96PIF, Glucocorticoid modulatory element-binding protein 1, GMEB 1 |
| 基因名称 | GMEB1 |
| 蛋白名称 | Glucocorticoid modulatory element-binding protein 1 (GMEB-1) (DNA-binding protein p96PIF) (Parvovirus initiation factor p96) (PIF p96) |
| 推荐应用 | |
| 反应物种 | Human,Mouse,Rat |
| 存储缓冲液 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Human Gene Link | 10691 |
| Human Swissprot No. | Q9Y692 |
| Mouse Gene ID | 56809 |
| Mouse Swissprot No. | Q9JL60 |
| Rat Gene ID | 500558 |
| Rat Swissprot No. | Q9QUZ8 |
| 特异性 | endogenous |
| 稀释度 | WB 1:1000-1:2500;IP 1:50-1:200;FC 1:100-1:500; |
| 参考分子量 | MW(Observed):63kDa |
| 预测分子量 | MW(Calculated):63kDa |
| 运输及保存条件 | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 宿主 | Rabbit |
| 同种型 | IgG,Kappa |
| 背景介绍 | This gene encodes a member of KDWK gene family which associates with GMEB2 protein. The GMEB1-GMEB2 complex is essential for parvovirus DNA replication. Studies in rat for a similar gene suggest that this gene's role is to modulate the transactivation of the glucocorticoid receptor when it is bound to glucocorticoid response elements. Three alternative spliced transcript variants encoding different isoforms exist. [provided by RefSeq, Feb 2016] |
| 细胞定位 | SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=May be also cytoplasmic. |
| 功能 | FUNCTION: Trans-acting factor that binds to glucocorticoid modulatory elements (GME) present in the TAT (tyrosine aminotransferase) promoter and increases sensitivity to low concentrations of glucocorticoids. Binds also to the transferrin receptor promoter. Essential auxiliary factor for the replication of parvoviruses. |
| 纯化 | Protein A |
| Clonality | Monoclonal |
| 修饰类型 | Unmodified |
| 细胞定位 | SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=May be also cytoplasmic. |
| 组织表达 | Widely expressed |
周一至周日 8:00-18:00
