cIAP2 Rabbit mAb-一抗-博克思生物科技

商品详情文献引用

别名	AIP 1;AIP1;API 2;API2;API2;Apoptosis inhibitor 2;Baculoviral IAP repeat containing 3;Baculoviral IAP repeat containing protein 3;Baculoviral IAP repeat-containing protein 3;BIRC 3;BIRC3;BIRC3;BIRC3_HUMAN;C IAP2;C-IAP2;CIAP 2;CIAP 2;CIAP2;HAIP 1;HAIP1;HAIP
基因名称	cIAP2
蛋白名称	Baculoviral IAP repeat-containing protein 3
推荐应用
反应物种	Human
存储缓冲液	PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Human Gene Link	330
Human Swissprot No.	Q13489
Mouse Swissprot No.	O08863
特异性	endogenous
稀释度	WB 1:1000-1:5000;ELISA 1:5000-1:20000;IP 1:50-1:200;
参考分子量	MW(Observed):68kD
预测分子量	MW(Calculated):68kD
运输及保存条件	-15°C to -25°C/1 year(Do not lower than -25°C)
宿主	Rabbit
同种型	IgG,Kappa
背景介绍	This gene encodes a member of the IAP family of proteins that inhibit apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. The encoded protein inhibits apoptosis induced by serum deprivation but does not affect apoptosis resulting from exposure to menadione, a potent inducer of free radicals. It contains 3 baculovirus IAP repeats and a ring finger domain. Transcript variants encoding the same isoform have been identified. [provided by RefSeq, Aug 2011],
细胞定位	Cytoplasm . Nucleus .
功能	Disease:A chromosomal aberration involving BIRC3 is recurrent in low-grade mucosa-associated lymphoid tissue (MALT lymphoma). Translocation t(11;18)(q21;q21) with MALT1. This translocation is found in approximately 50% of cytogenetically abnormal low-grade MALT lymphoma.,Function:Apoptotic suppressor. The BIR motifs region interacts with TNF receptor associated factors 1 and 2 (TRAF1 and TRAF2) to form an heteromeric complex, which is then recruited to the tumor necrosis factor receptor 2 (TNFR2).,similarity:Belongs to the IAP family.,similarity:Contains 1 CARD domain.,similarity:Contains 1 RING-type zinc finger.,similarity:Contains 3 BIR repeats.,subunit:Interacts with SMAC and with PRSS25; these interactions inhibit apoptotic suppressor activity.,tissue specificity:Highly expressed in fetal lung, and kidney. In the adult, expression is mainly seen in lymphoid tissues, including spleen, thymus and peripheral blood lymphocytes.,
纯化	Protein A
Clonality	Monoclonal
修饰类型	Unmodified
细胞定位	Cytoplasm . Nucleus .
组织表达	Highly expressed in fetal lung, and kidney. In the adult, expression is mainly seen in lymphoid tissues, including spleen, thymus and peripheral blood lymphocytes.
研究领域	>>Platinum drug resistance;>>NF-kappa B signaling pathway;>>Ubiquitin mediated proteolysis;>>Apoptosis;>>Apoptosis - multiple species;>>Necroptosis;>>Hippo signaling pathway;>>Focal adhesion;>>NOD-like receptor signaling pathway;>>TNF signaling pathway;>>Salmonella infection;>>Toxoplasmosis;>>Herpes simplex virus 1 infection;>>Pathways in cancer;>>Transcriptional misregulation in cancer;>>Small cell lung cancer

cIAP2 Rabbit mAb

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