| 别名 | BNIP3;NIP3;BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 |
| 基因名称 | BNIP-3 |
| 蛋白名称 | BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 |
| 推荐应用 | |
| 反应物种 | Human,Mouse,Rat |
| 存储缓冲液 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Human Gene Link | 664 |
| Human Swissprot No. | Q12983 |
| Mouse Swissprot No. | O55003 |
| 特异性 | endogenous |
| 稀释度 | WB 1:1000-1:5000;ELISA 1:5000-1:20000;IP 1:50-1:200; |
| 参考分子量 | MW(Observed):22-28kD,50-55kD |
| 预测分子量 | MW(Calculated):22kD |
| 运输及保存条件 | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 宿主 | Rabbit |
| 同种型 | IgG,Kappa |
| 背景介绍 | This gene is encodes a mitochondrial protein that contains a BH3 domain and acts as a pro-apoptotic factor. The encoded protein interacts with anti-apoptotic proteins, including the E1B 19 kDa protein and Bcl2. This gene is silenced in tumors by DNA methylation. [provided by RefSeq, Dec 2014], |
| 细胞定位 | Mitochondrion. Mitochondrion outer membrane; Single-pass membrane protein. Coexpression with the EIB 19-kDa protein results in a shift in NIP3 localization pattern to the nuclear envelope. Colocalizes with ACAA2 in the mitochondria. Colocalizes with SPATA18 at the mitochondrion outer membrane. |
| 功能 | Function:Apoptosis-inducing protein that, which can overcome BCL2 suppression. May play a role in repartitioning calcium between the two major intracellular calcium stores in association with BCL2.,similarity:Belongs to the NIP3 family.,subcellular location:Coexpression with the EIB 19-kDa protein results in a shift in NIP3 localization pattern to the nuclear envelope.,subunit:Homodimer. Binds to BCL2. Interacts with BNIP3L. Also can interact with adenovirus E1B 19 kDa protein or Epstein-Barr virus BHRF1., |
| 纯化 | Protein A |
| Clonality | Monoclonal |
| 修饰类型 | Unmodified |
| 细胞定位 | Mitochondrion. Mitochondrion outer membrane; Single-pass membrane protein. Coexpression with the EIB 19-kDa protein results in a shift in NIP3 localization pattern to the nuclear envelope. Colocalizes with ACAA2 in the mitochondria. Colocalizes with SPATA18 at the mitochondrion outer membrane. |
| 组织表达 | B-cell,Brain,Cerebellum,Kidney,Testis, |
| 研究领域 | >>FoxO signaling pathway;>>Mitophagy - animal;>>Autophagy - animal;>>Shigellosis;>>Legionellosis |
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