| 别名 | Vascular cell adhesion protein 1;V-CAM 1;VCAM-1;INCAM-100;CD antigen CD106; |
| 基因名称 | VCAM1 |
| 蛋白名称 | VCAM1 |
| 推荐应用 | |
| 反应物种 | Human,Mouse,Rat |
| 存储缓冲液 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Human Gene Link | 7412 |
| Human Swissprot No. | P19320 |
| Mouse Gene ID | 22329 |
| Mouse Swissprot No. | P29533 |
| Rat Gene ID | 25361 |
| Rat Swissprot No. | P29534 |
| 特异性 | endogenous |
| 稀释度 | IHC 1:500-1:1000;WB 1:1000-1:5000;IF 1:200-1:1000;ELISA 1:5000-1:20000;IP 1:50-1:200; |
| 参考分子量 | MW(Observed):110kD |
| 预测分子量 | MW(Calculated):81kD |
| 运输及保存条件 | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 宿主 | Rabbit |
| 同种型 | IgG,Kappa |
| 背景介绍 | This gene is a member of the Ig superfamily and encodes a cell surface sialoglycoprotein expressed by cytokine-activated endothelium. This type I membrane protein mediates leukocyte-endothelial cell adhesion and signal transduction, and may play a role in the development of artherosclerosis and rheumatoid arthritis. Three alternatively spliced transcripts encoding different isoforms have been described for this gene. [provided by RefSeq, Dec 2010], |
| 细胞定位 | Membrane; Single-pass type I membrane protein. |
| 功能 | Alternative products:Additional isoforms seem to exist,Disease:May play an important role in the genesis of atherosclerosis and rheumatoid arthritis.,Domain:Either the first or the fourth Ig-like C2-type domain is required for VLA4-dependent cell adhesion.,Function:Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with the beta-1 integrin VLA4 on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/VLA4 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation.,induction:By cytokines (e.g. IL-1, TNF-alpha).,online information:VCAM-1,online information:VCAM1 entry,PTM:Sialoglycoprotein.,similarity:Contains 7 Ig-like C2-type (immunoglobulin-like) domains.,subunit:Binds to ECMV-D capsid proteins and acts as a receptor for this virus.,tissue specificity:Expressed on inflamed vascular endothelium, as well as on macrophage-like and dendritic cell types in both normal and inflamed tissue., |
| 纯化 | Protein A |
| Clonality | Monoclonal |
| 修饰类型 | Unmodified |
| 细胞定位 | Membrane; Single-pass type I membrane protein. |
| 组织表达 | Expressed on inflamed vascular endothelium, as well as on macrophage-like and dendritic cell types in both normal and inflamed tissue. |
| 研究领域 | >>NF-kappa B signaling pathway;>>Cell adhesion molecules;>>TNF signaling pathway;>>Leukocyte transendothelial migration;>>AGE-RAGE signaling pathway in diabetic complications;>>African trypanosomiasis;>>Malaria;>>Lipid and atherosclerosis;>>Fluid shear stress and atherosclerosis |
周一至周日 8:00-18:00
