| 别名 | Sodium/potassium-transporting ATPase subunit alpha-1;Na;+;/K;+;ATPase alpha-1 subunit;Sodium pump subunit alpha-1; |
| 基因名称 | Na+/K+-ATPase |
| 蛋白名称 | Sodium/potassium-transporting ATPase subunit alpha-1 (Na(+)/K(+) ATPase alpha-1 subunit) (Sodium pump subunit alpha-1) |
| 推荐应用 | |
| 反应物种 | Human,Mouse,Rat |
| 存储缓冲液 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Human Gene Link | 476;477;478;480 |
| Human Swissprot No. | P05023;P50993;P13637;Q13733 |
| Rat Gene ID | 24211 |
| Rat Swissprot No. | P06685 |
| 特异性 | endogenous |
| 稀释度 | IHC 1:2000-1:10000;WB 1:10000-1:25000;IF 1:200-1:1000;ELISA 1:5000-1:20000;IP 1:50-1:200; |
| 参考分子量 | MW(Observed):100kD |
| 预测分子量 | MW(Calculated):113kD |
| 运输及保存条件 | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 宿主 | Rabbit |
| 同种型 | IgG,Kappa |
| 背景介绍 | ATPase Na+/K+ transporting subunit alpha 1(ATP1A1) Homo sapiens The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 1 subunit. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009], |
| 细胞定位 | Membranous |
| 功能 | Catalytic activity:ATP + H(2)O + Na(+)(In) + K(+)(Out) = ADP + phosphate + Na(+)(Out) + K(+)(In).,Function:This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.,PTM:Phosphorylation on Tyr-10 modulates pumping activity.,similarity:Belongs to the cation transport ATPase (P-type) family.,similarity:Belongs to the cation transport ATPase (P-type) family. Type IIC subfamily.,subcellular location:Identified by mass spectrometry in melanosome fractions from stage I to stage IV.,subunit:Composed of three subunits: alpha (catalytic), beta and gamma. Binds the HLA class II histocompatibility antigen, DR1., |
| 纯化 | Protein A |
| Clonality | Monoclonal |
| 修饰类型 | Unmodified |
| 细胞定位 | Membranous |
| 组织表达 | Kidney, Heart, Brain, Renal cell carcinoma, Glioma, Lung cancer |
| 研究领域 | >>cGMP-PKG signaling pathway;>>cAMP signaling pathway;>>Cardiac muscle contraction;>>Adrenergic signaling in cardiomyocytes;>>Insulin secretion;>>Thyroid hormone synthesis;>>Thyroid hormone signaling pathway;>>Aldosterone synthesis and secretion;>>Aldosterone-regulated sodium reabsorption;>>Endocrine and other factor-regulated calcium reabsorption;>>Proximal tubule bicarbonate reclamation;>>Salivary secretion;>>Gastric acid secretion;>>Pancreatic secretion;>>Carbohydrate digestion and absorption;>>Protein digestion and absorption;>>Bile secretion;>>Mineral absorption |
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