| 别名 | BCAS1;AIBC1;NABC1;Breast carcinoma-amplified sequence 1 ;Amplified and overexpressed in breast cancer;Novel amplified in breast cancer 1; |
| 基因名称 | BCAS1 |
| 蛋白名称 | Breast carcinoma-amplified sequence 1;Amplified and overexpressed in breast cancer;Novel amplified in breast cancer 1; |
| 推荐应用 | |
| 反应物种 | Human |
| 存储缓冲液 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Human Gene Link | 8537 |
| Human Swissprot No. | O75363 |
| 特异性 | endogenous |
| 稀释度 | WB 1:1000-5000； |
| 参考分子量 | MW(Observed):64kD |
| 预测分子量 | MW(Calculated):62kD |
| 运输及保存条件 | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 宿主 | Rabbit |
| 同种型 | IgG,Kappa |
| 背景介绍 | This gene resides in a region at 20q13 which is amplified in a variety of tumor types and associated with more aggressive tumor phenotypes. Among the genes identified from this region , it was found to be highly expressed in three amplified breast cancer cell lines and in one breast tumor without amplification at 20q13.2. However , this gene is not in the common region of maximal amplification and its expression was not detected in the breast cancer cell line MCF7 , in which this region is highly amplified. Although not consistently expressed , this gene is a candidate oncogene. |
| 细胞定位 | Cytoplasm. |
| 功能 | Required for myelination. {ECO:0000250|UniProtKB:Q80YN3}. |
| 纯化 | Protein A |
| Clonality | Monoclonal |
| 修饰类型 | Unmodified |
| 细胞定位 | Cytoplasm. |
| 组织表达 | Highly expressed in the brain and, more specifically, in oligodendrocytes (at protein level). Expressed in the prostate, and at lower levels in testis, intestine and colon. Overexpressed in most breast cancer cell lines and down-regulated in some colorectal tumors. {ECO:0000269|PubMed:10857754, ECO:0000269|PubMed:14567997, ECO:0000269|PubMed:29212715}. |
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