| 别名 | NFKBIE;IKBE;NF-kappa-B inhibitor epsilon ;NF-kappa-BIE;I-kappa-B-epsilon;IkB-E;IkB-epsilon;IkappaBepsilon; |
| 基因名称 | NFKBIE |
| 蛋白名称 | NF-kappa-B inhibitor epsilon;NF-kappa-BIE;I-kappa-B-epsilon;IkB-E;IkB-epsilon;IkappaBepsilon; |
| 推荐应用 | |
| 反应物种 | Human |
| 存储缓冲液 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Human Gene Link | 4794 |
| Human Swissprot No. | O00221 |
| 特异性 | endogenous |
| 稀释度 | WB 1:1000-1:2500； |
| 参考分子量 | MW(Observed):55kD |
| 预测分子量 | MW(Calculated):53kD |
| 运输及保存条件 | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 宿主 | Rabbit |
| 同种型 | IgG,Kappa |
| 背景介绍 | The protein encoded by this gene binds to components of NF-kappa-B, trapping the complex in the cytoplasm and preventing it from activating genes in the nucleus. Phosphorylation of the encoded protein targets it for destruction by the ubiquitin pathway, which activates NF-kappa-B by making it available to translocate to the nucleus. [provided by RefSeq, Sep 2011], |
| 细胞定位 | Cytoplasm. |
| 功能 | Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. Inhibits DNA-binding of NF-kappa-B p50-p65 and p50-c-Rel complexes. {ECO:0000269|PubMed:9315679}. |
| 纯化 | Protein A |
| Clonality | Monoclonal |
| 修饰类型 | Unmodified |
| 细胞定位 | Cytoplasm. |
| 组织表达 | Highly expressed in spleen, testis and lung, followed by kidney, pancreas, heart, placenta and brain. Also expressed in granulocytes and macrophages. |
| 研究领域 | >>Th1 and Th2 cell differentiation;>>Th17 cell differentiation;>>T cell receptor signaling pathway;>>B cell receptor signaling pathway;>>Neurotrophin signaling pathway;>>Adipocytokine signaling pathway;>>Epstein-Barr virus infection;>>PD-L1 expression and PD-1 checkpoint pathway in cancer |
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