| 别名 | CD34;Hematopoietic progenitor cell antigen CD34;CD antigen CD34 |
| 基因名称 | CD34 |
| 蛋白名称 | Hematopoietic progenitor cell antigen CD34 |
| 推荐应用 | |
| 反应物种 | Human,Mouse,Rat |
| 存储缓冲液 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Human Gene Link | 947 |
| Human Swissprot No. | P28906 |
| Mouse Gene ID | 12490 |
| Mouse Swissprot No. | Q64314 |
| 特异性 | endogenous |
| 稀释度 | IHC 1:1000-1:5000;WB 1:1000-1:2500;IF 1:200-1:1000;ELISA 1:5000-1:20000;IP 1:50-1:200; |
| 参考分子量 | MW(Observed):80kD |
| 预测分子量 | MW(Calculated):41kD |
| 运输及保存条件 | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 宿主 | Rabbit |
| 同种型 | IgG,Kappa |
| 背景介绍 | The protein encoded by this gene may play a role in the attachment of stem cells to the bone marrow extracellular matrix or to stromal cells. This single-pass membrane protein is highly glycosylated and phosphorylated by protein kinase C. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011], |
| 细胞定位 | Membrane; Single-pass type I membrane protein. |
| 功能 | Alternative products:Both isoforms are expressed on the cell surface. CD34-T/CD34-F ratio increases with cell differentiation,developmental stage:On early hematopoietic progenitor cells.,Disease:Abnormal CD34 expression in leukemogenesis.,Function:Possible adhesion molecule with a role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. Could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. Presents carbohydrate ligands to selectins.,online information:CD34 entry,PTM:Highly glycosylated.,PTM:Phosphorylated on serine residues by PKC.,similarity:Belongs to the CD34 family.,tissue specificity:Selectively expressed on hematopoietic progenitor cells and the small vessel endothelium of a variety of tissues., |
| 纯化 | Protein A |
| Clonality | Monoclonal |
| 修饰类型 | Unmodified |
| 细胞定位 | Membrane; Single-pass type I membrane protein. |
| 组织表达 | Selectively expressed on hematopoietic progenitor cells and the small vessel endothelium of a variety of tissues. |
| 研究领域 | >>Cell adhesion molecules;>>Hematopoietic cell lineage |
周一至周日 8:00-18:00
