| 别名 | ERG |
| 基因名称 | ERG |
| 蛋白名称 | Transcriptional regulator ERG (Transforming protein ERG) |
| 推荐应用 | |
| 反应物种 | Human,Mouse,Rat, |
| 存储缓冲液 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Human Gene Link | 2078 |
| Human Swissprot No. | P11308 |
| Mouse Gene ID | 13876 |
| Mouse Swissprot No. | P81270 |
| 特异性 | endogenous |
| 稀释度 | IHC 1:100-1:500;WB 1:1000-1:5000;IF 1:200-1:1000;ELISA 1:5000-1:20000;IP 1:50-1:200; |
| 参考分子量 | MW(Observed):55kD |
| 预测分子量 | MW(Calculated):55kD |
| 运输及保存条件 | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 宿主 | Rabbit |
| 同种型 | IgG,Kappa |
| 背景介绍 | This gene encodes a member of the erythroblast transformation-specific (ETS) family of transcriptions factors. All members of this family are key regulators of embryonic development , cell proliferation , differentiation , angiogenesis , inflammation , and apoptosis. The protein encoded by this gene is mainly expressed in the nucleus. It contains an ETS DNA-binding domain and a PNT (pointed) domain which is implicated in the self-association of chimeric oncoproteins. This protein is required for platelet adhesion to the subendothelium , inducing vascular cell remodeling. It also regulates hematopoesis , and the differentiation and maturation of megakaryocytic cells. This gene is involved in chromosomal translocations , resulting in different fusion gene products , such as TMPSSR2-ERG and NDRG1-ERG in prostate cancer , EWS-ERG in Ewing's sarcoma and FUS-ERG in acute myeloid leukemia. More than two dozens of transcript variants generated from combinatorial usage of three alternative promoters and multiple alternative splicing events have been reported , but the full-length nature of many of these variants has not been determined. |
| 细胞定位 | Nucleus |
| 功能 | Transcriptional regulator. May participate in transcriptional regulation through the recruitment of SETDB1 histone methyltransferase and subsequent modification of local chromatin structure. |
| 纯化 | Protein A |
| Clonality | Monoclonal |
| 修饰类型 | Unmodified |
| 细胞定位 | Nucleus |
| 组织表达 | Endothelium, Prostate, Bone marrow, Prostate cancer, Ewing sarcoma, Acute myeloid leukemia |
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