| 别名 | Seprase;170 kDa melanoma membrane-bound gelatinase;Fibroblast activation protein alpha;Integral membrane serine protease; |
| 基因名称 | FAP-1 |
| 蛋白名称 | Seprase (170 kDa melanoma membrane-bound gelatinase) (Fibroblast activation protein alpha) (Integral membrane serine protease) |
| 推荐应用 | |
| 反应物种 | Human, |
| 存储缓冲液 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Human Gene Link | 2191 |
| Human Swissprot No. | Q12884 |
| Mouse Gene ID | 14089 |
| Mouse Swissprot No. | P97321 |
| 特异性 | endogenous |
| 稀释度 | WB 1:1000-1:2500； |
| 参考分子量 | MW(Observed):87kD |
| 预测分子量 | MW(Calculated):87kD |
| 运输及保存条件 | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 宿主 | Rabbit |
| 同种型 | IgG,Kappa |
| 背景介绍 | The protein encoded by this gene is a homodimeric integral membrane gelatinase belonging to the serine protease family. It is selectively expressed in reactive stromal fibroblasts of epithelial cancers, granulation tissue of healing wounds, and malignant cells of bone and soft tissue sarcomas. This protein is thought to be involved in the control of fibroblast growth or epithelial-mesenchymal interactions during development, tissue repair, and epithelial carcinogenesis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2014], |
| 细胞定位 | Membrane |
| 功能 | Catalytic activity:Degrades gelatin and heat-denatured type I and type IV collagen, but not native type I or type IV collagen. Does not cleave laminin, fibronectin, fibrin or casein.,Function:May have a role in tissue remodeling during development and wound healing, and may contribute to invasiveness in malignant cancers.,induction:In fibroblasts at times and sites of tissue remodeling during development, tissue repair, and carcinogenesis.,PTM:N-glycosylated.,PTM:The N-terminus may be blocked.,similarity:Belongs to the peptidase S9B family.,subcellular location:Found in cell surface lamellipodia, invadopodia and on shed vesicles.,subunit:Homodimer, or heterodimer with DPP4. The monomer is inactive.,tissue specificity:Fibroblast specific., |
| 纯化 | Protein A |
| Clonality | Monoclonal |
| 修饰类型 | Unmodified |
| 细胞定位 | Membrane |
| 组织表达 | Expressed in adipose tissue. Expressed in the dermal fibroblasts in the fetal skin. Expressed in the granulation tissue of healing wounds and on reactive stromal fibroblast in epithelial cancers. Expressed in activated fibroblast-like synoviocytes from inflamed synovial tissues. Expressed in activated hepatic stellate cells (HSC) and myofibroblasts from cirrhotic liver, but not detected in normal liver. Expressed in glioma cells (at protein level). Expressed in glioblastomas and glioma cells. Isoform 1 and isoform 2 are expressed in melanoma, carcinoma and fibroblast cell lines. |
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