| 别名 | YAP1;YAP65;Yorkie homolog;65 kDa Yes-associated protein;YAP65 |
| 基因名称 | YAP1 |
| 蛋白名称 | Yorkie homolog |
| 推荐应用 | |
| 反应物种 | Human,Mouse,Rat, |
| 存储缓冲液 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Human Gene Link | 10413 |
| Human Swissprot No. | P46937 |
| Mouse Gene ID | 22601 |
| Mouse Swissprot No. | P46938 |
| Rat Gene ID | 363014 |
| Rat Swissprot No. | Q2EJA0 |
| 特异性 | endogenous |
| 稀释度 | IHC 1:100-1:500;WB 1:500-1:2000;IF 1:200-1:1000;ELISA 1:5000-1:20000;IP 1:50-1:200; |
| 参考分子量 | MW(Observed):70kD |
| 预测分子量 | MW(Calculated):55kD |
| 运输及保存条件 | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 宿主 | Rabbit |
| 同种型 | IgG,Kappa |
| 背景介绍 | This gene encodes a downstream nuclear effector of the Hippo signaling pathway which is involved in development, growth, repair, and homeostasis. This gene is known to play a role in the development and progression of multiple cancers as a transcriptional regulator of this signaling pathway and may function as a potential target for cancer treatment. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2013], |
| 细胞定位 | Cytoplasm, Nucleus |
| 功能 | PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Contains 1 WW domain.,subunit:Binds to the SH3 domain of the YES kinase. Binds to WBP1 and WBP2. Binds, in vitro, through the WW1 domain, to neural isoforms of ENAH that contain the PPSY motif., |
| 纯化 | Protein A |
| Clonality | Monoclonal |
| 修饰类型 | Unmodified |
| 细胞定位 | Cytoplasm, Nucleus |
| 组织表达 | Increased expression seen in some liver and prostate cancers. Isoforms lacking the transactivation domain found in striatal neurons of patients with Huntington disease (at protein level). |
| 研究领域 | >>Hippo signaling pathway;>>Hippo signaling pathway - multiple species |
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