| 别名 | SPP1;BNSP;OPN;PSEC0156;Osteopontin;Bone sialoprotein 1;Nephropontin;Secreted phosphoprotein 1;SPP-1;Urinary stone protein;Uropontin |
| 基因名称 | SPP1 |
| 蛋白名称 | Osteopontin |
| 推荐应用 | |
| 反应物种 | Human,Mouse,Rat, |
| 存储缓冲液 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Human Gene Link | 6696 |
| Human Swissprot No. | P10451 |
| Mouse Gene ID | 20750 |
| Mouse Swissprot No. | P10923 |
| Rat Gene ID | 25353 |
| Rat Swissprot No. | P08721 |
| 特异性 | endogenous |
| 稀释度 | WB 1:1000-1:5000；ELISA 1:5000-1:20000 |
| 参考分子量 | MW(Observed):55,65kD |
| 预测分子量 | MW(Calculated):35kD |
| 运输及保存条件 | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 宿主 | Rabbit |
| 同种型 | IgG,Kappa |
| 背景介绍 | secreted phosphoprotein 1(SPP1) Homo sapiens The protein encoded by this gene is involved inThe attachment of osteoclasts toThe mineralized bone matrix.The encoded protein is secreted and binds hydroxyapatite with high affinity.The osteoclast vitronectin receptor is found inThe cell membrane and may be involved inThe binding to this protein. This protein is also a cytokine that upregulates expression of interferon-gamma and interleukin-12. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011], |
| 细胞定位 | Secreted |
| 功能 | Disease:This protein plays a principal role in urinary stone formation as the stone matrix.,Function:Acts as a cytokine involved in enhancing production of interferon-gamma and interleukin-12 and reducing production of interleukin-10 and is essential in the pathway that leads to type I immunity.,Function:Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction.,online information:Osteopontin entry,PTM:Extensively phosphorylated on clustered serine residues.,PTM:N- and O-glycosylated.,similarity:Belongs to the osteopontin family.,subunit:Ligand for integrin alpha-V/beta-3., |
| 纯化 | Protein A |
| Clonality | Monoclonal |
| 修饰类型 | Unmodified |
| 细胞定位 | Secreted |
| 组织表达 | Bone. Found in plasma. |
| 研究领域 | >>PI3K-Akt signaling pathway;>>Apelin signaling pathway;>>Focal adhesion;>>ECM-receptor interaction;>>Toll-like receptor signaling pathway;>>GnRH secretion;>>Human papillomavirus infection |
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