| 别名 | Paired box protein Pax-5 (B-cell-specific transcription factor) (BSAP) |
| 基因名称 | PAX5 |
| 蛋白名称 | PAX-5 |
| 推荐应用 | |
| 反应物种 | Human,Mouse,Rat, |
| 存储缓冲液 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Human Gene Link | 5079 |
| Human Swissprot No. | Q02548 |
| Mouse Gene ID | 18507 |
| Mouse Swissprot No. | Q02650 |
| 特异性 | endogenous |
| 稀释度 | IHC 1:1000-1:4000;WB 1:1000-1:5000;IF 1:200-1:1000;ELISA 1:5000-1:20000;IP 1:50-1:200; |
| 参考分子量 | MW(Observed):42kD |
| 预测分子量 | MW(Calculated):42kD |
| 运输及保存条件 | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 宿主 | Rabbit |
| 同种型 | IgG,Kappa |
| 背景介绍 | The enzyme encoded by this gene catalyzes the first 2 steps, and at least 1 subsequent step, in the conversion of tyrosine to melanin. The enzyme has both tyrosine hydroxylase and dopa oxidase catalytic activities, and requires copper for function. Mutations in this gene result in oculocutaneous albinism, and nonpathologic polymorphisms result in skin pigmentation variation. The human genome contains a pseudogene similar to the 3' half of this gene. [provided by RefSeq, Oct 2008] |
| 细胞定位 | Nucleus |
| 功能 | Developmental stage:Expressed at early B-cell differentiation, in the developing CNS and in adult testis.,disease:A chromosomal aberration involving PAX5 is a cause of acute lymphoblastic leukemia. Translocation t(9;18)(p13;q11.2) with ZNF521. Translocation t(9;3)(p13;p14.1) with FOXP1. Translocation t(9;12)(p13;p13) with ETV6.,Function:May play an important role in B-cell differentiation as well as neural development and spermatogenesis. Involved in the regulation of the CD19 gene, a B-lymphoid-specific target gene.,PTM:O-glycosylated.,similarity:Contains 1 paired domain.,subunit:Interacts with DAXX (By similarity). Binds DNA as a monomer. Binds TLE4., |
| 纯化 | Protein A |
| Clonality | Monoclonal |
| 修饰类型 | Unmodified |
| 细胞定位 | Nucleus |
| 组织表达 | Spleen, Lymph node, Tonsil, B-cell lymphoma, Chronic lymphocytic leukemia, Follicular lymphoma |
周一至周日 8:00-18:00
