| 别名 | SIRT3;SIR2L3;NAD-dependent protein deacetylase sirtuin-3;mitochondrial;hSIRT3;Regulatory protein SIR2 homolog 3;SIR2-like protein 3 |
| 基因名称 | SIRT3 |
| 蛋白名称 | NAD-dependent protein deacetylase sirtuin-3 mitochondrial |
| 推荐应用 | |
| 反应物种 | Human,Mouse,Rat, |
| 存储缓冲液 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Human Gene Link | 23410 |
| Human Swissprot No. | Q9NTG7 |
| Mouse Swissprot No. | Q8R104 |
| 特异性 | endogenous |
| 稀释度 | WB 1:1000-1:2500；ELISA 1:5000-1:20000 |
| 参考分子量 | MW(Observed):28kD |
| 预测分子量 | MW(Calculated):44kD |
| 运输及保存条件 | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 宿主 | Rabbit |
| 同种型 | IgG,Kappa |
| 背景介绍 | This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Two alternatively spliced transcript variants that encode different proteins have been described for this gene. [provided by RefSeq, Jul 2008], |
| 细胞定位 | Mitochondrion matrix |
| 功能 | Catalytic activity:NAD(+) + an acetylprotein = nicotinamide + O-acetyl-ADP-ribose + a protein.,cofactor:Binds 1 zinc ion per subunit.,Function:NAD-dependent deacetylase. Despite some ability to deacetylate histones in vitro, it is unlikely in vivo.,PTM:Processed by mitochondrial processing peptidase (MPP) to give a 28 kDa product. Such processing is probably essential for its enzymatic activity.,similarity:Belongs to the sirtuin family.,similarity:Contains 1 deacetylase sirtuin-type domain.,tissue specificity:Widely expressed., |
| 纯化 | Protein A |
| Clonality | Monoclonal |
| 修饰类型 | Unmodified |
| 细胞定位 | Mitochondrion matrix |
| 组织表达 | Widely expressed. |
| 研究领域 | >>Nicotinate and nicotinamide metabolism;>>Metabolic pathways;>>Central carbon metabolism in cancer |
周一至周日 8:00-18:00
