货号：BSCY0124
Optineurin;E3-14.7K-interacting protein;FIP-2;Huntingtin yeast partner L;Huntingtin-interacting protein 7;HIP-7;Huntingtin-interacting protein L;NEMO-related protein;Optic neuropathy-inducing protein;Transcription factor IIIA-interacting protein;TFIIIA-In
| 别名 | Optineurin;E3-14.7K-interacting protein;FIP-2;Huntingtin yeast partner L;Huntingtin-interacting protein 7;HIP-7;Huntingtin-interacting protein L;NEMO-related protein;Optic neuropathy-inducing protein;Transcription factor IIIA-interacting protein;TFIIIA-In |
| 基因名称 | OPTN |
| 蛋白名称 | OPTN |
| 推荐应用 | |
| 反应物种 | Human,Mouse,Rat, |
| 存储缓冲液 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Human Gene Link | 10133 |
| Human Swissprot No. | Q96CV9 |
| Mouse Gene ID | 71648 |
| Mouse Swissprot No. | Q8K3K8 |
| Rat Gene ID | 246294 |
| Rat Swissprot No. | Q8R5M4 |
| 特异性 | endogenous |
| 稀释度 | IHC 1:200-500;WB 1:1000-1:2500;IF 1:200-1000;ELISA 1:5000-20000;IP 1:50-200 |
| 参考分子量 | MW(Observed):74kD |
| 预测分子量 | MW(Calculated):63kD |
| 运输及保存条件 | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 宿主 | Rabbit |
| 同种型 | IgG,Kappa |
| 背景介绍 | This gene encodes the coiled-coil containing protein optineurin. Optineurin may play a role in normal-tension glaucoma and adult-onset primary open angle glaucoma. Optineurin interacts with adenovirus E3-14.7K protein and may utilize tumor necrosis factor-alpha or Fas-ligand pathways to mediate apoptosis , inflammation or vasoconstriction. Optineurin may also function in cellular morphogenesis and membrane trafficking , vesicle trafficking , and transcription activation through its interactions with the RAB8 , huntingtin , and transcription factor IIIA proteins. Alternative splicing results in multiple transcript variants encoding the same protein. |
| 细胞定位 | Cytoplasm |
| 纯化 | Protein A |
| Clonality | Monoclonal |
| 修饰类型 | Unmodified |
| 细胞定位 | Cytoplasm |
| 组织表达 | Present in aqueous humor of the eye (at protein level). Highly expressed in trabecular meshwork. Expressed nonpigmented ciliary epithelium, retina, brain, adrenal cortex, fetus, lymphocyte, fibroblast, skeletal muscle, heart, liver, brain and placenta. |
| 研究领域 | >>Mitophagy - animal;>>Amyotrophic lateral sclerosis;>>Pathways of neurodegeneration - multiple diseases |
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