| 别名 | KLF4;EZF;GKLF;Krueppel-like factor 4;Epithelial zinc finger protein EZF;Gut-enriched krueppel-like factor |
| 基因名称 | KLF4 |
| 蛋白名称 | Krueppel-like factor 4 |
| 推荐应用 | |
| 反应物种 | Human,Mouse,Rat, |
| 存储缓冲液 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Human Gene Link | 9314 |
| Human Swissprot No. | O43474 |
| Mouse Swissprot No. | Q60793 |
| 特异性 | endogenous |
| 稀释度 | IHC 1:200-1000;WB 1:1000-1:2500;IF 1:200-1000;ELISA 1:5000-20000;IP 1:50-200 |
| 参考分子量 | MW(Observed):60kD |
| 预测分子量 | MW(Calculated):55kD |
| 运输及保存条件 | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 宿主 | Rabbit |
| 同种型 | IgG,Kappa |
| 背景介绍 | This gene encodes a protein that belongs to the Kruppel family of transcription factors. The encoded zinc finger protein is required for normal development of the barrier function of skin. The encoded protein is thought to control the G1-to-S transition of the cell cycle following DNA damage by mediating the tumor suppressor gene p53. Mice lacking this gene have a normal appearance but lose weight rapidly, and die shortly after birth due to fluid evaporation resulting from compromised epidermal barrier function. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015], |
| 细胞定位 | Nuclear |
| 功能 | Function:Transcription factor which acts as both an activator and repressor. Binds the CACCC core sequence. Binds to multiple sites in the 5'-flanking region of its own gene and can activate its own transcription. Required for establishing the barrier function of the skin and for postnatal maturation and maintenance of the ocular surface. Involved in the differentiation of epithelial cells and may also function in skeletal and kidney development.,similarity:Belongs to the krueppel C2H2-type zinc-finger protein family.,similarity:Contains 3 C2H2-type zinc fingers.,subunit:Interaction with the C-terminal domain of MUC1 enhances suppression of TP53/p53 transcription., |
| 纯化 | Protein A |
| Clonality | Monoclonal |
| 修饰类型 | Unmodified |
| 细胞定位 | Nuclear |
| 组织表达 | Cervix,Lung,Placenta,Substantia nigra,Tongue, |
| 研究领域 | >>Signaling pathways regulating pluripotency of stem cells;>>Chemical carcinogenesis - receptor activation |
周一至周日 8:00-18:00
